Posted by Jedi on April 26, 2007, at 2:06:52
In reply to Re: Great Nardil experience, posted by stevezen on April 25, 2007, at 23:27:41
> hey everyone!
> sowwy, I don't mean to put a damper on your MAOI parade. been on the ol' parnate half way through week 6, now at 50mg's and nothing doing :(
> in fact, if anything it's making my depression worse! is that possible? ...Hi,
I've been at 80mg for a month and I still have my bad days. In fact I've had about three in a row. I've been on Nardil for most of ten years so maybe the side effects for me are not as bad as they would be if I started Parnate with no experience with MAOIs. It is difficult to find the dosage that your body needs and then stick with it for six or eight weeks, especially if the side effects are bad.Dr. Goldman of Depression Central writes that the biggest reason tranylcypromine doesn't work for a patient is not a high enough dosage for a long enough time. He also uses stimulants to augment tranylcypromine.
Hang in there,
Jedi
Pharmacopsychiatry. 1989 Jan;22(1):21-5.
High dose tranylcypromine therapy for refractory depression.Amsterdam JD, Berwish NJ.
Department of Psychiatry, School of Medicine, University of Pennsylvania, Philadelphia.A substantial number of depressed patients will experience a chronic, treatment-resistant affective disorder. Aggressive treatment of these patients with various drug combinations, unconventional antidepressants, or electroconvulsive therapy has met with only partial success. There remains a pressing need to identify more effective methods of utilizing "first-line" antidepressant agents to achieve a more rapid therapeutic action. To this end, we initiated a study using high doses of the MAO inhibitor tranylcypromine, at a range of 90 mg to 170 mg daily, in seven refractory depressed patients who had failed to respond to at least three prior treatments regimens. Four out of seven subjects (57%), who had failed to respond to a mean of 8 +/- 5 prior treatment, had a complete response, and one patient had a partial response to high dose tranylcypromine. The mean SD maximum tranylcypromine dose for the responders was 112 +/- 16 mg daily (range 90 mg to 130 mg). Response did not appear to be a function of severity of illness, duration of present episode, or the number of prior treatment failures. Overall, the side effect profile was favorable, and no "cheese reactions" were encountered. These observations are of clinical significance and suggest the need for further controlled studies using high doses of tranylcypromine.
poster:Jedi
thread:625238
URL: http://www.dr-bob.org/babble/20070419/msgs/753510.html