Posted by psychobot5000 on May 1, 2007, at 16:17:06
In reply to Re: Noradrenergics for motivation, focus, anhedoni, posted by linkadge on May 1, 2007, at 6:22:58
Sounds as though most people on this thread seem to feel that noradrenergics may not directly be useful for these.
>
> There is at least one selective dopamine reuptake inhibitor in the pipelines. Apparently it has low affinity for neucleus accumbens transporters and has little abuse potential.
>This is good, but let me theorize what might be best: a dopamine reuptake inhibitor with -high- affinity for the nucleus accumbens, which could be bonded to a molecule that would make it inert until processed (and released from the bond) by the liver, at a rate limited by the quantity of liver-enzyme available--just as they've done with amphetamine.
Potentially, this might create a drug that might effectively fight anhedonia, without significant abusability. It would be impossible to flood the system with an active form of the chemical.
Aside from wishful thinking, it just occurred to me to mention that I found EPA fish oil (1-2g daily) seemed to help immediately with these issues. It was genuinely helpful beyond stimulants or any antidepressant I can think of, for anhedonia. Problem was, it wouldn't let me sleep, which naturally caused havoc. But maybe it would be useful for some anhedonics.
Psychbot
PS. Anyone find nomifensine any more useful for motivation or anhedonia than the NA specific meds?
poster:psychobot5000
thread:754423
URL: http://www.dr-bob.org/babble/20070426/msgs/754977.html