Posted by sukarno on May 22, 2007, at 6:56:58
In reply to Re: Wistar Kyoto rats on Nicotine, posted by linkadge on May 21, 2007, at 9:47:43
That's interesting. Thanks for the post about that. :-) Nicotine isn't all that bad when used alone in a clean delivery system such as gum, patch, or inhaler (not too sure of the inhaler's safety though). I think it was being investigated in ADD/ADHD with results showing efficacy approaching that or equivalent with methylphenidate (Ritalin).
It is quite dopaminergic to say the least. There is a component in tobacco smoke that inhibits MAO-B, thus prolonging and enhancing the effect of nicotine. I wonder if that psychoactive compound can be isolated from tobacco and if it is carcinogenic? I think it has never been identified.
Nicotine is rather benign (not carcinogenic) though when used alone as you said. The only contraindications or precautions I would see are those with borderline-high or high blood pressure, clotting disorders, recent myocardial infarction or stroke or other cardiovascular disease or taking birth control medication. A relatively healthy person would probably do well on pharmaceutical nicotine used in therapeutic doses. It would be quite exciting to see if it was of use in depression in humans. :-)
poster:sukarno
thread:758554
URL: http://www.dr-bob.org/babble/20070509/msgs/758762.html