Posted by psychobot5000 on May 26, 2007, at 23:58:41
In reply to Re: Clonidine or Guanfacine with MAOis » psychobot5000, posted by kaleidoscope on May 26, 2007, at 16:29:13
> Hi
>
> Clonidine is generally quite sedating. It has been used in children to control overactivity and impulsive aggression - I wouldn't expect it to improve concentration but I could be wrong.
>Jury's still out on that one. Apparently the alpha 2 agonism is relevant to certain aspects of attention. But they can apparently be sedating, too, as one would expect from such vascular medications.
Guanfacine, the purer alpha2 agonist (clonidine seems to cause unnecessary sedation through alpha 1 blocking), seems likely to be approved in an extended release form for ADD, presumably because of this action on attention (see Connexyn).
Best,
Psychbot
poster:psychobot5000
thread:759656
URL: http://www.dr-bob.org/babble/20070524/msgs/759737.html