Posted by Larry Hoover on August 6, 2007, at 15:51:40
In reply to Re: Prestiq (Desvenlafaxine Succinate) » Cecilia, posted by kaleidoscope on August 6, 2007, at 15:05:45
> Prestiq will be an effective AD....... but will present all the same problems as Effexor. Patients who have had side effects from, or who have not benefitted from Effexor will almost certainly find that Prestiq is no better.
>
> KO-desmethyl-venlafaxine, or desvenlafaxine, is the product of cytochrome 2D6 action on the parent molecule......and I've been pondering this for a while.....but I wonder if Pristiq might not be of benefit to that 1 in 10 of us with little or no 2D6 activity.
A parallel situation may exist in e.g. the codeine/morphine pair. Codeine is O-desmethylated by 2D6 to morphine, making codeine a de facto time release form of morphine, but if and only if you have substantial 2D6 activity. People like me, with little or no 2D6 action, get all of the side effects of codeine but none of the benefits of morphine.
If a similar pattern holds, then Pristiq might be worth a trial by people who could not tolerate Effexor.
Just my thoughts....
Lar
poster:Larry Hoover
thread:773437
URL: http://www.dr-bob.org/babble/20070730/msgs/774349.html