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Re: SSRIs and bone loss

Posted by linkadge on August 21, 2007, at 19:50:02

In reply to Re: SSRIs and bone loss, posted by linkadge on August 21, 2007, at 19:37:22

Does anyone have any idea what percentage of tranporter occupancy a TCA would produce at theraputic concentrations?

I am not of the belief that a certain SERT binding is necessary to produce and AD effect.

NRi's are better REM supressors than SSRI's, and multiplicity of action probably means less of each target is necessary to produce an effect.

Linkadge



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URL: http://www.dr-bob.org/babble/20070815/msgs/777665.html