Posted by Quintal on August 23, 2007, at 22:28:28
In reply to Re: Parnate/Dexedrine/500 sleeping meds, please he, posted by jhj on August 23, 2007, at 8:22:22
Hi jhj,
Small amounts of codeine are sold over-the-counter at pharmacies here in the UK, so they are legal in some contexts. Psychiatrists have successfully used buprenorphine to treat severe depression refractory to mainstream treatments.
____________________________________________________1: J Clin Psychopharmacol. 1995 Feb;15(1):49-57.Click here to read Links
Buprenorphine treatment of refractory depression.
Bodkin JA, Zornberg GL, Lukas SE, Cole JO.McLean Hospital, Consolidated Department of Psychiatry, Harvard Medical School, Belmont, MA 02178, USA.
Opiates were used to treat major depression until the mid-1950s. The advent of opioids with mixed agonist-antagonist or partial agonist activity, with reduced dependence and abuse liabilities, has made possible the reevaluation of opioids for this indication. This is of potential importance for the population of depressed patients who are unresponsive to or intolerant of conventional antidepressant agents. Ten subjects with treatment-refractory, unipolar, nonpsychotic, major depression were treated with the opioid partial agonist buprenorphine in an open-label study. Three subjects were unable to tolerate more than two doses because of side effects including malaise, nausea, and dysphoria. The remaining seven completed 4 to 6 weeks of treatment and as a group showed clinically striking improvement in both subjective and objective measures of depression. Much of this improvement was observed by the end of 1 week of treatment and persisted throughout the trial. Four subjects achieved complete remission of symptoms by the end of the trial (Hamilton Rating Scale for Depression scores < or = 6), two were moderately improved, and one deteriorated. These findings suggest a possible role for buprenorphine in treating refractory depression.
PMID: 7714228 [PubMed - indexed for MEDLINE]
__________________________________________________Amphetamines are drugs of abuse, yet have legitimate medical indications. The same goes for benzodiazepines; the clobazam you're taking, for example, is a Class C drug here in the UK, the same category as cannabis, ketamine, and GHB. All of these drugs can alleviate suffering and have legitimate medical indications in some contexts, and so long as they are obtained via prescription at a pharmacy, and treatment is properly supervised by a doctor, most people will have few problems with them, whatever their legal status.
Q
poster:Quintal
thread:777910
URL: http://www.dr-bob.org/babble/20070815/msgs/778216.html