Posted by KayeBaby on September 2, 2007, at 2:28:00
In reply to at the closed ward and given solian, posted by Jeroen on August 30, 2007, at 11:10:55
> at the closed ward and given solian 200 mg
>
> in the morning, i also have dystonia blepharospasm
>
> how will this affect me? the solian
>
> hi philippa, well yes 2 hours time i have for thisJeron,
I am so sorry to hear this. You must be so frustrated. It's really late, but I did a little reading on your condition. Here is a hopeful bit of information. This is about using Botox to stop the blinking.I hope you find some relief soon.
Your friend,
Kaye
Management
There are only few controlled therapeutic trials in blepharospasm, but recent refinements in clinical rating scales should facilitate future studies [Lindeboom et al, 1995]. Although botulinum toxin (BTX) injections into the eyelids and eyebrows is considered by many as the treatment of choice, some patients with blepharospasm obtain satisfactory relief from medications, particularly clonazepam (1-8 mg/day) or trihexyphenidyl (2-12nag/day). BTX injections provide moderate or marked improvement in over 90% of patients. The average latency from the time of the injection to the onset of improvement is 2 to 5 days and the average duration is 3 to 4 months. Following BTX treatments, as a result of reduced eyelid and eyebrow spasms, most patients can function normally and they have less difficulties driving, watching TV, or reading. In addition to the observed functional improvement, there is usually a meaningful amelioration of discomfort and, because of less embarrassment, the patients' self-esteem also frequently improves. Although about 10-15 % of all treatment sessions are followed by some side effects (ptosis, blurring of vision or diplopia, tearing, and local hematoma), the complications only rarely affect patient's functioning and usually resolve spontaneously in less than 2 weeks. There is no apparent decline in benefit and the frequency of complications actually decreases after repeat BTX treatments [Jankovic and Schwartz, 1993]. Botulinum toxin F may be a useful alternative for those rare patients who develop blocking antibodies to botulinum toxin A, but its usefulness is limited by substantially shorter duration of benefit [Mezaki et al, 1995]. In a double-blind study of 212 consecutive patients with essential blepharospasm, who received one injection of Botox and one injection of Dysport in two separate treatment sessions, using empirical ratio Botox:Dysport of 1:4 M, the average dose of Botox per treatment was 45.4 IU +/- 13.3 (range 25-85 IU) and of Dysport 182.1 IU +/- 55.1 (range 100-340 IU. There was no difference in the duration of the effect (about 8 weeks), but side effects, particularly ptosis, was more frequent with Dysport as compared to Botox (24. 1 % vs. 17.0%) (P < 0.05).
poster:KayeBaby
thread:779743
URL: http://www.dr-bob.org/babble/20070831/msgs/780314.html