Posted by August on September 5, 2007, at 11:53:06
In reply to Selegiline + Buproprion?, posted by Mrsmith on September 4, 2007, at 11:18:57
"experiencing psychostimulant burn-out - some paradoxical fatigue; hyperfocus without executive direction - so unimportant stuff distracts while high priority items ignored; most important - anhedonia and amotivation."Your description of your Selegiline experience very closely describes my two times (2003 & 2007) with Selegiline. My increased focus and initiative could sometimes get "hijacked" on some unimportant project.
Both times Selegiline initially seemed to be the long sought after "cure" -- at least during the first 7 to 10 days of use. Then it abruptly lost any positive impact and seemed to actually cause a low mood.
In 2003 I took 2 1/2 mg in the AM. This initially caused a great mood lift with resulting focus, clear thinking, and all-day productivity. This dosage also caused major nightly insomnia.
In 2007 I tried it again, starting at about .63 mg
(later increasing to 1.25 mg). I experienced the same initial positive results. In both 2003 and 2007 the good results lasted for about the first 10 days of a 20 day trial.The first time I took only Selegiline. The second time I took the low dose Selegiline and continued taking my low dose Surmontil (3 mg) in the evening for sleep.
While, this combination is supposedly dangerous, I tried it since I had my most success with very a combination of very low dosages of Parnate - 2mg / day (another MAOI) and Surmontil 3mg /day.
I've tried using only Surmontil but found that a small amount of Parnate in the early afternoon
helped.I am back on the low dose Parnate + Surmontil combo. It hasn't cure me since I still have trouble with my initiative and productivity for the important tasks (Abulic depression).
An aside observation. Since 1989 I've trialed most ADs. If the initial dosage didn't work my docs always raised the dosage (often creating lots of confusion, slow thinking, missing words, etc.).
Sometime along the way I found that I actually did better on very low amounts (supposedly non-therapeutic amounts) of almost any psycho med I took (e.g 1mg of Restirol - a pinch of powder from a 15 mg capsule) is enough to break through insomnia and provide a good night's sleep.
Researchers are learning more about medicine metabolism. While some folks can metabolize 90% of their prescribed med others might metabolize only 10%. If their doc triples their dosage the efficient metabolizers get 270% which may be too much. The inefficient metabolizers get only 30% which may still be below a therapeutic dose.
I believe I fall into the efficient metabolize category, so increasing the dosage often produced side effects, not therapy.
poster:August
thread:780764
URL: http://www.dr-bob.org/babble/20070831/msgs/780967.html