Posted by Astounder on November 1, 2007, at 23:03:36
In reply to Re: zoloft and risperidol, posted by monkeysmama on October 31, 2007, at 7:45:58
> Thanks for the responses. I lowered my dose last week to 25 and got in trouble. lol. She wasn't a fan of my adjusting my own medication. I think I need to be on 25 mg. though... Do you know if these word recognition (I believe that is the word you used) problems will clear up over time?
Are you taking the Risperdal for schizophrenia or for depression? If it's depression, I think you'd be better off lowering the dose of the Risperdal, not the Zoloft. Risperdal's benefit in depression is from its 5-HT2a blocking which attenuates the initial anxiety and insomnia SSRIs cause and augments the mood elevation, but this effect maxes out at .5 to 1 mg with Risperdal (Risperdal has the highest 5-HT2a to D2 affinity among all neuroleptics). Any higher and you start to meaningfully block D2, making it act more as an antipsychotic: This can weaken cognition, block pleasure, and sometimes causing an intense, restless anxiety called akathisia.
poster:Astounder
thread:792428
URL: http://www.dr-bob.org/babble/20071027/msgs/792873.html