Posted by Larry Hoover on November 5, 2007, at 16:45:35
In reply to Re: Wellbutrin Stimulation?? When does it start? » clubfitter, posted by Astounder on November 2, 2007, at 19:42:01
> Keep in mind the original clinical trials for Wellbutrin went up to 900 mg/d. They warn against going this high because of a seizure risk, but the original trials where they first noticed this were in high-risk populations using the instant-release formulation. Even then the risk is not much higher than some tricyclics. So you might want to talk to your doctor about raising the dose.
I'm very uncomfortable with this assertion. Prior to 2004, the Wellbutrin monograph listed seizure risks of: at 300 mg/day, 0.1%; at 450, 0.4%; at 600, 4%. The latter risk value was subsequently revised down to 2.3% All are based on t.i.d. dosing of IR bupropion. B.i.d. intake would lead to greater fluctuation in blood concentrations, and thus would likely present a greater risk than suggested by these data.
If you plot these data, you will obtain an exponential curve. If you take enough bupropion, you will seize. The unfortunate truth is that we cannot predict an individual's seizure threshold dose, beforehand. Instead, we have to use a risk/benefit analysis. That has led to placing a maximum intake at 450 mg/day.
Lar
poster:Larry Hoover
thread:793032
URL: http://www.dr-bob.org/babble/20071104/msgs/793462.html