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Re: picking up 6 months supply of amisulpride tomorrow » iforgotmypassword

Posted by kaleidoscope on November 9, 2007, at 11:51:37

In reply to picking up 6 months supply of amisulpride tomorrow, posted by iforgotmypassword on November 8, 2007, at 17:59:06

Hi IFMP,

That's good news that your got the amisulpride. I hope you find it helpful.

About the letter....

Whenever a doctor prescribes a drug which is not approved in their country, the doctor (and not the manufacturer) has to take legal responsibility for any toxicity which may occur. Basically, if you had a serious cardiac arrhythmia, the resposibility would lie with your psychiatrist. This is why the manufacturer wanted to make sure that your doctor was aware of the risks, however small.

In countries where amisulpride is approved, such as the UK, it comes with a cardiac warning.

Here is the UK warning......

Amisulpride induces a dose-dependent prolongation of the QT interval.

This effect, known to potentiate the risk of serious ventricular arrhythmias such as torsades de pointes is enhanced by the pre-existence of bradycardia, hypokalaemia, congenital or acquired long QT interval.

Hypokalaemia should be corrected.

Before any administration, and if possible according to the patient's clinical status, it is recommended to monitor factors which could favour the occurrence of this rhythm disorder:

- bradycardia less than 55 bpm,

- hypokalaemia,

- congenital prolongation of the QT interval.

- on-going treatment with a medication likely to produce pronounced bradycardia (< 55 bpm), hypokalaemia, decreased intracardiac conduction, or prolongation of the QTc interval


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