Posted by bulldog2 on November 17, 2007, at 13:14:42
In reply to Re: Mechanism Of Action Of Nardil » bulldog2, posted by Racer on November 17, 2007, at 12:26:30
> > With the ssris you get a steady decline over time which might account for people saying they feel like zombies.
>
> Actually, most of what I've read says that the down-regulation of 5HT receptors on SSRIs actually increases the ratio of DA, rather than lowering it. I'd be interested in seeing the sources for this statement.You would think that if the ratio of DA to SE were increased libido would be increased and people would have more of a pleasure response in general which people on ssris frequently complain they don't have.
Here's a excerpt from an article on ssris.
Sexual side effects
See also: Post SSRI Sexual Dysfunction
SSRIs can cause various types of sexual dysfunction such as anorgasmia, erectile dysfunction, and diminished libido. Initial studies found that such side effects occur in less than 10% of patients, but since these studies relied on unprompted reporting, the frequency was probably underestimated. In more recent studies, doctors have specifically asked about sexual difficulties, and found that they are present in between 17% [17] and 41% [18] of patients. This dysfunction occasionally disappears spontaneously without stopping the SSRI, and in most cases resolves after discontinuation. In some cases, however, it does not; this is known as Post SSRI Sexual Dysfunction (PSSD).It is believed that sexual dysfunction is caused by an SSRI induced reduction in dopamine. Stimulation of postsynaptic 5-ht2 and 5-ht3 receptors decreases dopamine release from the Substantia Nigra. Sexual dysfunction caused by SSRIs can sometimes be mitigated by several different drugs. These include:
bupropion (norepinephrine and dopamine reuptake inhibitor)
buspirone (serotonin receptor agonist)
methylphenidate (stimulant)
mirtazapine (noradrenergic and specific serotonergic antidepressant (NaSSA))
amphetamine (stimulant)
amantadine (antiviral)
pramipexole (dopamine agonist) and
ropinirole (dopamine agonist)
On the other hand, the effect of SSRIs to slow down sexual stimulation may be used as treatment; SSRIs have been proposed as a drug to treat premature ejaculation.[19]
poster:bulldog2
thread:795513
URL: http://www.dr-bob.org/babble/20071115/msgs/795572.html