Posted by linkadge on December 9, 2007, at 14:37:18
In reply to I guess it comes down to the question you ask » linkadge, posted by Racer on December 9, 2007, at 13:53:17
>First of all, I wonder what criteria is being >used to "prove" that "Placebo response to >psychiatric drugs is very high?"
I am not sure what you mean. The fact that it can be often difficult to establish a superiority of certain medications to placebo is fairly well known.
>I won't waste my energy asking for citations for >that statement. I'll only state that I am >skeptical, and that the criteria used to assess >any response will necessarily affect the outcome >of any study.
For instance, it is true that more than half of all SSRI clinical trials fail to demonstrate superiority of drug over placebo. I insert no interpretation to that, its simply what it is.
>So, when you state that "the majority of >lamotrigine clinical trials fail to show any >statistical significance," I would ask for >details of study design, and how that design >might influence outcome.
The GSK clinical registry is open to the lay public. You can go on, and review the trials if you like.
>Your posts seem very negative about medication >efficacy.
Well, I am only really discussing lamotrigine. The reason being that, like the gabapentin fiasco, I think it is usefull to routeenly discuss the effects of certain medications.
I think people diserve effective treatments. So, I was really wanting to discuss these aspects of lamotrigine.
Linkadge
poster:linkadge
thread:799578
URL: http://www.dr-bob.org/babble/20071204/msgs/799753.html