Posted by ny2bk on December 13, 2007, at 8:41:21
Just to give an idea on how using single documents or views can be a bit misleading,im leaving the following link.It speaks about parnate,now reason i am is because parnate in general,as in most standerd general searches and many threads here is a maoi that does not have a effect on GABA opposed to NARDIL which has an amazing effect on it.
I believe its saying parnate increases upregulation which makes one more sensative to gaba drugs.Personly i can attest to this as benzos definatly seem more potent along side parnate.There tons of examples such as this,where info is often see-sawed and now im very careful with how i take in info.
My recomendation personaly is to create on your pc desktop a folder named maybe MEDINFO and save documents and threads you find informative,and allow yourself a fair view of information on hand.Here below is the link and pasted article.
Insights welcome.http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&uid=16927039&cmd=showdetailview&indexed=google
Tranylcypromine: new perspectives on an "old" drug.Frieling H, Bleich S.
Department of Psychiatry and Psychotherapy, Friedrich-Alexander-University of Erlangen-Nuremberg, Schwabachanlage 6, 91054 Erlangen, Germany. helge.frieling@psych.imed.uni-erlangen.deThe irreversible inhibitor of monoamine oxidase, tranylcypromine, is a potent antidepressant, but its use is limited to special indications due to side effects and dietary restrictions. The antidepressant action of tranylcypromine is not completely explainable by its effects on monoamine oxidase. Tranylcypromine also leads to an increase in brain trace amines, which are believed to play a key role in the pathophysiology of depression. It also affects other pathophysiological pathways associated with depression. Tranylcypromine treatment leads to an up-regulation of GABA(B)-receptors and modulates the phospholipid metabolism, which is essential for normal brain function. These findings implicate that the efficacy of tranylcypromine as an antidepressant may be due to its multiple actions within the human brain.
PMID: 16927039 [PubMed - indexed for MEDLINE
poster:ny2bk
thread:800522
URL: http://www.dr-bob.org/babble/20071213/msgs/800522.html