Posted by jedi on December 15, 2007, at 1:21:37
In reply to MAOIs and WEAK SRIs combination?, posted by amigan on December 14, 2007, at 23:55:49
Hi,
Trazodone in low dosage is often used as a sleep aid with Nardil. I have used it myself. I have also augmented Nardil with Nortriptyline, mostly as a sleep aid. There is some evidence that this type of TCA will help reduce the chance of a tyramine reaction with Nardil. I've taken nefazodone but don't know about any reaction with a MAOI.
Jedi
> Hello.
> I known that the combination of a MAOI with a potent serotonine reuptake inhibitor like all(?) SSRIs and certain TCAs like clomipramine can easily lead to a life-threatening, serotonine syndrome.
> But, would it be relatively safe to combine a MAOI with a low dose of a WEAK SRI, like trazodone, nefazodone or nortriptyline?
> Furthermore, some of these ADs are also blocking certain 5-HT receptors, which could be beneficial in preventing the development of a serotonine syndrome! (On the other hand, things might be more complicated with traz/nefazodone, as they are metabolized into mCPP which is a 5-HT agonist... but anyway, i refer them as an example)
>
> What do you think?
>
poster:jedi
thread:800899
URL: http://www.dr-bob.org/babble/20071213/msgs/800905.html