Posted by Squiggles on December 22, 2007, at 13:56:07
In reply to Please if anyone can help answer....., posted by ny2bk on December 22, 2007, at 10:08:26
I have no personal experience. Looking at the
Nemeroff handbook, I read that it is in the Typical Antipsycbotic Class (typically used for psychosis, schizophrenia, Alzheimer's or mania first stage), its primary effect like others in this class is Sedation.Mechanism: blocks postsynaptic DA (D1 D2 D3 D4)
receptors and/or act as antagonists at alpha1-adregenergic, serotenergic, histaminergic,
and cholinergic receptors.In a comparative table MOBAN -trade name or Molindone is as some others 3x less sedating than Thorazine (Chropromazine), Mellaril (Thioridazine), and Serentil (Mesoridazine);
3x less Anticholinergic to the ones above, and 3x less orthostatic hypotensive inducing to the above. However, it shares 3x to 2x as high EPS effects, as all the typical antipsychotics, except the ones mentioned above.EPS effects can be treated by a variety of drugs
like beta-blockers and Benadryl.Dr. Kevin Thompson gives a list of serious
side effects from these drugs in his book
"Medicines for Mental Health".For QT prolongation, the worst typical antypsychotics are:
Chlorpromazine, Droperidol, Haloperidol, Mesoridazine, Pimozide, Thioridazine, and Zotepine.
The principal drawback of all are:
Tardive Dyskinesia
Neuroleptic Malignant Syndrome
QT prolongation -- a heart block or arrhythmia
Extra Pyramidal Syndromes
Dystonia
Parkinsonism
AkathisiaChlorpromazine is the first antipsychotic
from the 50s. They are powerful drugs, it
seems and what one might call "carpet-bombing".That's what i found in my books. Maybe 2nd
generation antipsychotics are used now for
schizophrenia and psychosis.Squiggles
poster:Squiggles
thread:802046
URL: http://www.dr-bob.org/babble/20071213/msgs/802076.html