Posted by 30years on December 28, 2007, at 14:24:08
In reply to Re: Budeprion (Generic) vs. Wellbutrin, posted by sdworaczyk on December 6, 2007, at 8:52:06
I honestly don't understand the complaints between the brand-name and the generics. I've been on anti-depressents for the worst kind of depression for about 30 years now and have never noticed any difference going from brand-name to generics. Generics are the identical chemical composition as the brand-names (such as Wellbutrin).
The New England Journal of Medicine reports that "Generic-drug manufacturers must establish bioequivalence to the active ingredients of the original drug and demonstrate adherence to FDA-approved manufacturing processes."
I've been switched from Wellbutrin XL to Budeprion XL and now to Bupropion HCL--all contiain the chemical makeup of "bupropion HCL." I've never had new side effects or noticed any difference in efficaciousness. Same is true for all the generics I've been on the last 30 years.
The ONLY thing that might make a difference is if the XL (extended release) process is different in the differing generics versus the brand-name drug--i.e., if the extended release of the drug is somehow not equivalent over time. Seems the FDA oversight of the manufacturing process should also eliminate any problems there as well.
Perhaps Dr-Bob has some insight.
poster:30years
thread:397165
URL: http://www.dr-bob.org/babble/20071225/msgs/803039.html