Posted by tapiocamonk on January 6, 2008, at 16:37:14
In reply to Re: Nardil: My Experience Thus Far.... » tapiocamonk, posted by tecknohed on January 6, 2008, at 11:38:07
> I was on Nardil nearly 4 years.
>
> Give 60mg at least another 2 weeks before increasing. For me it kicked in as soon as I hit 60mg at 3 weeks. DONT jump strait to 90mg. If you need to, increase to 75mg 1st.I'm going to follow your advice here and wait it out at 60mg before raising.
Question though: I've heard that it takes more Nardil to do the trick since the reformulation by Pfizer; were you on the old formulation or the new and do you think it matters?
>
> It sounds like you have social anxiety? Then best to spread the doses out as much as poss. For depression alone once daily is ok but for anxiety you need to spread it out because its Nardil's metabolite that increases GABA, & because Nardil has a very short half life you want that metabolite circulating throughout the day. At 60mg I took 30mg morn, 15mg lunch & 15mg early eve for socializing.That's very interesting. I hadn't heard any of that before about GABA and the short half life. I'm going to follow your advice here too and spread the dose.
Question: do you think spreading the dose will have any positive or negative effect on daytime sedation and possible insomnia? I think I can deal with the daytime sedation, but I dealt with MAOI insomnia for years on Parnate and am definitely not looking forward to a return of that.
>
> Daytime sedation IS a side effect of Nardil. Normally happens shortly after dosing over 15mg at a time. One way to deal with it is to DO SOMETHING. Keep active. Read, watch TV or browse the Net & you'll fall asleep. Public transport journeys were also a nightmare for me - I'd often ride the train or bus & fall asleep & miss my stop! Solved this by listening to loud music on headphones.
> Marplan, another MAOI which I take now also gives me some daytime sedation shortly after dosing but I've solved this with nootropics, the most efficient one being Acetyl-L-Carnitine.
>
> I'm afraid that sexual side effects are likely to creep up on you eventually. Its usually the last side effect to appear, normally soon after Nardil really kicks in. But it does go on its own accord after several months. And its usually anorgasmia, not low libido.If I had to choose, I would take anorgasmia over low libido any day of the week. I feel like if the Nardil kicks in and I can start behaving like a normal person, getting involved socially and maybe even having a girlfriend and having a sex drive on top of that, I'll just deal with the anorgasmia when it comes up.
>>Marplan has already given me anorgasmia, but I've solved this with a herbal supplement called Horney Goat Weed. Heres a thread I started on it: http://www.dr-bob.org/babble/alter/20071031/msgs/801401.html
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> Another poster on here, Darius2535, said that a combo of Cyproheptadine 4mg + Bethanechol 50mg solved his/her anorgasmia from Nardil.
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> I NEVER had insomnia from Nardil myself. In fact in the long run it increased my hypersomnia I already suffer from (for most of my life).
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> By the sounds of things you're already on your way to being a Nardil winner! I had what you have - a subtle improvement in socializing & mood almost right from the start. Then for me, within 4 weeks BAM! My personality changed like Nardil had switched some sort of light on. Sounds like you're on that path too. I hope so. Just dont be too hasty. Nardil is a very delicate drug & requires delicate dosing. Be as patient as you can.
>
> Good luck!
> teckThanks so much for your advice. I really hope everything that you say will prove true and that Nardil will flip that switch with my personality.
poster:tapiocamonk
thread:804488
URL: http://www.dr-bob.org/babble/20080105/msgs/804666.html