Posted by brot on January 8, 2008, at 12:22:31
"....To date, there is no effective treatment against BDV infection..."
I hope this substance described below will make it on the market someday soon. I do have antibodies for BDV (Borna Disease Virus). No Virus in the blood sample. But it is not known if the virus is able to "hide" in the brain. Maybe.... There is a study on apes in Japan where they found active Borna Virus in the brain tissue of an ape.
I would love to try this substance and see.. but its soo damn expensive and I dont known if it is tested on humans at all.------------------------
Antimicrob Agents Chemother. 2004 Apr;48(4):1422-5.2'-fluoro-2'-deoxycytidine inhibits Borna disease virus replication and spread.
Bajramovic JJ, Volmer R, Syan S, Pochet S, Gonzalez-Dunia D.Unité des Virus Lents, CNRS URA 1930, Institut Pasteur, Paris, France.
Borna disease virus (BDV) causes neurological diseases in a variety of warm-blooded animal species, possibly including humans. To date, there is no effective treatment against BDV infection. Recently, we reported on the antiviral activity of 1-beta-D-arabinofuranosylcytosine (Ara-C). However, Ara-C's cytotoxic side effects are a major obstacle for its therapeutic use. Herein, we demonstrate that the nucleoside analog 2'-fluoro-2'-deoxycytidine (2'-FdC) exhibits potent antiviral activity against BDV. Importantly, 2'-FdC-associated cytotoxicity is negligible, indicating 2'-FdC as an excellent candidate for the development of antiviral therapy against BDV.
PMID: 15047559 [PubMed - indexed for MEDLINE]
poster:brot
thread:805093
URL: http://www.dr-bob.org/babble/20080105/msgs/805093.html