Posted by yxibow on February 22, 2008, at 3:09:21
In reply to Does taking vitamin E while using an AP..., posted by Jamal Spelling on February 20, 2008, at 7:54:57
> ...reduce the risk of TD?
>
> What other ways are there to reduce the risk of TD?It isn't harmful, I used to take it for neuroprotection ideas, however there have been no studies that have proven any of this. I wouldn't take more than the standard 400 IU -- it has multiple issues including thinning blood and I recall some recent medical study that suggested limiting high tocopherol intake. If you are taking it, you might as well take mixed tocopherols.
http://en.wikipedia.org/wiki/Tocopherol
Yes, it has been used in extremely small studies at 1600 IU for TD but this also has never been proven at all. At that level it probably is not the best thing to be taking daily as it somewhat exceeds the highest set normal intake.
Low amounts are used as a food preservative.
The simple answer since Chlorpromazine in 1954 is there is no way of particularly curing or absolutely preventing TD*. But there are ways of greatly minimizing the risk. This includes regular AIMS examinations of a patient (subjective muscular, leg, finger, arm questions), and using the MED, minimum effective dose on a patient.* TD also remits in 30% of the cases at least, reduces in another 30% and becomes worse in the remaining. Clozaril/clozapine has been the only atypical shown to actually improve the life of patients with TD. It does have a rigorous required FDA blood monitoring program and there are at least 3-4 manufacturers with national registries.
As mentioned before, this is roughly the current medical view :
http://www.leeheymd.com/medmemo/fall04.html
5% per year up to around 25% lifetime for the strongest typicals, not forgetting this is an individual variation and no patient may show this. Risperdal is about the only atypical shown at the moment to actually have some documented cases of TD.
Again, TD choreiform movements in patients can appear being neurological or biochemical in nature without any relation to the medication at all.
So the answer is, it is informed consent basically, and having a doctor that continues to monitor with AIMS, and discussing your options that you feel most comfortable with for an AP, that are also of course effective.
-- Jay
poster:yxibow
thread:813725
URL: http://www.dr-bob.org/babble/20080221/msgs/814047.html