Posted by Dopamine123 on February 25, 2008, at 10:51:54
In reply to Re: Lexapro for 2 weeks... now somethings gone wro, posted by jms600 on February 23, 2008, at 10:27:51
"From what you have written above, are you saying that Remeron would be the best AD for > me to try?"
Nope, its just one possiblity I gave. If it didn't work for you, then don't try it again.
"I have tried Remeron some time back, and I have to say it was the worst AD I have ever taken! It did nothing but exacerbate my anxiety. In fact, out of all the ADs I have tried Remeron has to be the worst!"
Well remeron increases norepinephrine at higher doses due to its effect on alpha-2 adrenergic receptor, so it was probably increasing anxiety through that mechanism. So the dose you were on was probably too high.
http://www.preskorn.com/columns/0003.html
"However, higher doses of mirtazapine result in the blockade of the alpha-2 adrenergic receptor, which produces an alerting or arousal effect just like yohimbine and just the opposite of the sedation produced by the alpha-2 adrenergic agonist, clonidine."Every person's brain is different, that's why I gave 3 different things you could try. Your on an antipsychotic anyway, so you might want to try a different antipsychotic.
http://www.preskorn.com/columns/0003.html
"Agonism of the 5-HT1A receptor is currently believed to be the mechanism mediating the antidepressant efficacy of these drugs. Conversely, agonism of the 5-HT2A, 5HT2C, and 5-HT3 receptors may principally mediate the adverse effects of these drugs: sleep disturbance, anxiety and weight gain, and nausea/loose stools/vomiting, respectively."
poster:Dopamine123
thread:812520
URL: http://www.dr-bob.org/babble/20080221/msgs/814587.html