Posted by SLS on February 26, 2008, at 7:04:20
In reply to Lar, SLS, Link: Magnesium blocks Neurontin?, posted by iforgotmypassword on February 25, 2008, at 23:43:08
Hi.
This is the sort of thing that seems more hypothetical than clinical. Try the Mg and see how it affects you once you have established a stable response to the Neurontin. You know that Neurontin and Lyrica both attach to the alpha2delta subunit of the calcium channel. This is a very depressogenic property for me. Mg might actually stabilize the feedback loop and help establish a further reduction in excessive neurotransmitter vesicular release for those neurons affected by Ca2+ influx. If the bulk of the neurons affected by Neurontin and Lyrica are GABA, this can produce an activating effect rather than a sedating one.
That is pure conjecture on my part, and a rather simplistic one at that. One thing that Neurontin does not do is to block Mg receptors. I don't see how they can be competitive for the same membrane receptor sites. It is interesting that both drugs can be sedating at first.
- Scott
poster:SLS
thread:814737
URL: http://www.dr-bob.org/babble/20080221/msgs/814757.html