Posted by Phillipa on March 14, 2008, at 17:21:03
In reply to Re: Cytokines, Inflammation, and Depression » seldomseen, posted by Phillipa on March 14, 2008, at 17:11:42
This one I did a search so how do you reduce them especially if genes are involved? Phillipa
Performing your original search, Cytokines, inflammation, depression, in PubMed will retrieve 485 citations.
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1: Trends Immunol. 2006 Jan;27(1):24-31. Epub 2005 Nov 28. Links
Cytokines sing the blues: inflammation and the pathogenesis of depression.Raison CL, Capuron L, Miller AH.
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 101 Woodruff Circle, Suite 4000, Atlanta, GA 30322, USA.Increasing amounts of data suggest that inflammatory responses have an important role in the pathophysiology of depression. Depressed patients have been found to have higher levels of proinflammatory cytokines, acute phase proteins, chemokines and cellular adhesion molecules. In addition, therapeutic administration of the cytokine interferon-alpha leads to depression in up to 50% of patients. Moreover, proinflammatory cytokines have been found to interact with many of the pathophysiological domains that characterize depression, including neurotransmitter metabolism, neuroendocrine function, synaptic plasticity and behavior. Stress, which can precipitate depression, can also promote inflammatory responses through effects on sympathetic and parasympathetic nervous system pathways. Finally, depression might be a behavioral byproduct of early adaptive advantages conferred by genes that promote inflammation. These findings suggest that targeting proinflammatory cytokines and their signaling pathways might represent a novel strategy to treat depression.
PMID: 16316783 [PubMed - indexed for MEDLINE]
poster:Phillipa
thread:817907
URL: http://www.dr-bob.org/babble/20080303/msgs/817955.html