Posted by undopaminergic on March 23, 2008, at 14:15:59
In reply to High blood pressure on Selegiline!, posted by Amigan on March 22, 2008, at 12:08:38
> Hello.
> Has anyone noticed an increase on his blood pressure while he/she is on Selegiline?
> I do, although i'm not 100% sure that Selegiline is responsible for this, but it is the prime suspect. I only take a micro dose of Sulpiride with it, currently.
> I take 10-15mg orally. Although, dietary restriction is not nessecary at this dosage, i do avoid tyramine-rich foods, so the rise in my BP is not tyramine related.
> So.. I basically want to ask 2 things:
>
> a)Has anyone else experienced this?Transiently, at some point when starting it, I noticed such a tendency. On the other hand, many people have experienced a hypotensive effect (even more so with L-dopa).
> b) what is the best medical approach to treat Seleiline-induced hypertension?
> Ca-blockers?
> B-blockers?
> ACE inhibitors + a diuretic?
> Don't suggest clonidine, please. I know that it should be effective, but it also kind-of cancels the effect of Selegiline due the sedation it causes.The most logical agents would seem to be alpha1-adrenergic antagonists (doxazosin, prazosin, etc.) and alpha2-adrenergic agonists (guanfacine, guanabenz). I've used guanfacine, as it has been shown to improve working memory and ADHD (those benefits are more subtle, however, than with stimulants - especially in cases complicated by other symptroms such as apathy and lack of energy).
poster:undopaminergic
thread:819397
URL: http://www.dr-bob.org/babble/20080316/msgs/819537.html