Posted by Widgetry on March 30, 2008, at 20:49:10
Im getting sicker and sicker I think my Selegiline (prescribed for off-label use of my death-defying depression) is causing a cascade of symptoms rivaling "Serotonin Syndrome (and mimicking symptoms I experienced 20 some years ago as a result of Industrial Chemical Exposure).
After much reading ... I thought I was onto ... "hope" when I started reading about "Rasagiline" ... thinking that ... as Selegiline is a Perkinson's drug that can be used "off label" for depression ... why can't "Ragagiline" (which is the "new" Perkinson's drug) be used "off label" for depression. Before you say it yes this was rather simple/wishful thinking on my part.
Where I've run into trouble is around the issue of MAO-A & MAO-B inhibitors. From reading the following link: http://www.ncbi.nlm.nih.gov/pubmed/3148140
It states:
MAO-A inhibitors are effective therapeutic agents in treating depression
MAO-B inhibitors are of questionable antidepressant efficacy"Rasagiline is an investigational selective and irreversible inhibitor of MAO-B that has demonstrated efficacy and safety for the treatment of PD. Whether rasagiline is associated with clinically significant neuroprotection is the subject of ongoing clinical trials
Two questions:- If a drug does not target MAO-A inhibitors will it not work as an anti-depressant?
- Has anyone out there tried Rasagiline as an off-label anti-depressant?
Thanks for your time.
poster:Widgetry
thread:820788
URL: http://www.dr-bob.org/babble/20080330/msgs/820788.html