Re: Seroquel is used to help with depression?

Posted by Dopamine123 on March 30, 2008, at 21:43:12

In reply to Re: Seroquel is used to help with depression?, posted by undopaminergic on March 27, 2008, at 18:04:57

Well I think it is complicated.
http://www.med.nyu.edu/psych/psychiatrist/depression/slides/sld035.html
>The selective activation of postsynaptic 5-HT1A receptors by buspirone in the presence of the presynaptic 5-HT1A antagonist pindolol appears to induce a rapid and robust antidepressant response.
Activation of postsynaptic 5-ht1a receptors has antidepressant properties. Antagonism of 5-ht1a autoreceptors can increase serotonin in the synapse and actually lead to increased activation of postsynaptic 5-ht1a receptors. So a drug like pindolol is a 5-ht1a antagonist, but it increases serotonin in the synapse because it blocks the autoreceptor.
See the picture at this website (buspirone is a 5-ht1a agonist while pindolol is an antagonist):
http://www.med.nyu.edu/psych/psychiatrist/depression/slides/sld036.html
Its confusing, but in the end seroquel probably leads to an increased activation of postsynaptic 5-ht1a receptors.
My blog:
http://brainstimulant.blogspot.com

Thread

Seroquel is used to help with depression? Ramin 3/26/08
Re: Seroquel is used to help with depression? undopaminergic 3/27/08
Re: Seroquel is used to help with depression? Dopamine123 3/30/08
i am on seroquel so here is how i feel ... Jeroen 4/6/08

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