Posted by bulldog2 on April 26, 2008, at 19:10:47
In reply to B-12 methylcobalomine caused me to relapse, posted by SLS on April 26, 2008, at 17:47:58
> Adding sublingual B-12 methylcobalomin to my treatment regime precipitated a complete relapse into severe depression. It lasted for about 24 hours after a single 1mg dose. I then challenged myself with Cerefolin, an oral medical preparation that contains methylcobalomin 2mg. I experienced a significant worsening of depression, but milder and of shorter duration. I have since recovered. At least I came away from this experience with some knowledge regarding my negative reactivity to this substance.
>
> Anyone else react this way to methylcobalomin B-12? Any clues as to what happened?
>
> Thanks.
>
>
> - Scott
>
>
>I suspect an interaction bewteen the deplin (folate) and homocysteine. Deplin causes homocysteine to convert to SAMe. Maybe you produced to much SAMe and that had a negative impact on your mood. Too much SAMe can be agitating and aggravate depression.
poster:bulldog2
thread:825625
URL: http://www.dr-bob.org/babble/20080420/msgs/825651.html