Posted by yxibow on May 7, 2008, at 1:36:14
In reply to To Jeron, posted by Zyprexa on May 6, 2008, at 17:38:26
> have you tried any older AP's? Perphenazine is working real well for me. I take it with cogentin to prevent TD. Have you tried cogentin for your eyes blinking?
I don't want to scare you but Cogentin (benztropine) is an anticholinergic and does not prevent TD. It allows you to tolerate EPS (extrapyramidal, or side effects).
If someone truly diagnosed with TD.....
(that's why I question these things because I have asked has a trained neurologist in movement disorders seen Jeroen -- there are other conditions that are not TD. I'm not saying someone trained hasn't already done so and I don't wish to beleaguer or malign what is already known).....
.... takes an anticholinergic (for reasons that psychiatry has yet to answer) is very likely to have an attack of their TD symptoms. Anticholinergics have never been proven to mask TD. Other substances have been used to fight TD but there have never been double blind studies and effectiveness hasn't been proven. This includes astronomical amounts of BuSpar (around 1600mg), very high IU of vitamin E, and two related drugs, dopamine depleters/blockades, that have shown signs but have a lot of risks --
Reserpine (an old naturally derived drug from India, not a very good idea), and Tetrabenazine (Nitoman, which is available in Canada and 10 other countries and is approved investigationally I believe as an orphan drug in the US).
Tetrabenazine can cause psychosis and all sorts of other things in those predisposed as well as Reserpine but the main issue is that it is unknown whether it will continue to cause or help TD -- recent studies at Baylor college have shown that it has drastically reduced TD at the expense of possible -permanent- pseudoparkinsonism.
-- tidings
poster:yxibow
thread:826646
URL: http://www.dr-bob.org/babble/20080430/msgs/827692.html