Posted by SLS on May 11, 2008, at 15:34:04
In reply to Re: modafinil and armodafinil, how do they differ? » SLS, posted by Larry Hoover on May 11, 2008, at 14:22:22
Thanks, Larry. I hadn't been aware of these findings. It's nice when some association can be seen between the pure research and the clinical observation. It makes me think that we are not as blind to the inner workings of the black box than we were only a decade ago.
- Scott
****************************************************> > > It may be worth emphasising that if you're using modafinil, then you're using armodafinil, because modafinil is a mixture of one part armodafinil, and one part of its mirror image, S-modafinil.
> >
> > It is interesting, though, that the clinical properties of Lexapro differ from that of Celexa. Lexapro tends to be more stimulating (except at the two-week mark, where it can produce transient fatigue). Some people respond robustly to one and not the other. There was some conjecture that the the r-isomer actually interferes with some of the clinical benefit from the s-isomer.
> It's more than conjecture. R-citalopram is a serotonin reuptake inhibitor inhibitor. It modifies the conformation of the receptor complex by binding at a site other than the active site. The effect is most dramatic in those with one specific serotonin transporter gene allele.
poster:SLS
thread:828224
URL: http://www.dr-bob.org/babble/20080510/msgs/828522.html