Posted by maz81 on June 2, 2008, at 7:34:57
There is some controversy as to the use of antidepressants in bipolar depression. The recent STEP-BD study (Sachs et al), suggest they are of no use. In response to this Rif S. El-Mallakh, M.D. has suggested this may be due to the fact that AD's were used in addition to mood stabilizers and that the mood stabilizers could have blocked the anti-depressant effect.
This is particularly interesting to me as I have bipolar depression and have failed about 10 antidepressant trials, whilst all along I have been taking one mood stabilizer or another. In the past when I just had unipolar depression, I responded quite well to AD's.
Wondered if anyone has any thoughts or insights.
poster:maz81
thread:832472
URL: http://www.dr-bob.org/babble/20080528/msgs/832472.html