Posted by undopaminergic on June 3, 2008, at 0:40:41
In reply to Re: SLS - riluzole, posted by SLS on June 2, 2008, at 2:38:11
>
> > Do you think a glutamate-enhancing type of AD would tend to have such effects?
>
> Modafinil (Provigil), a glutamate release enhancer, destroyed me. It made me very dumb and left me in a fog. It exacerbated my depression greatly.
>Your experience with modafinil is remarkable. It generally has the opposite effects on most people, although I did read of one other person who noted effects of the same character as you do, but with much less intensity.
I think modafinil's glutamate enhancement is an effect downstream of its dopaminergic reuptake inhibition. Cocaine and amphetamine also increase glutamate efflux in several regions, including prefrontal cortex and nucleus accumbens, and this effect is prevented by dopamine D1- and D2-receptor antagonists.
Do you react better to the other stimulants?
poster:undopaminergic
thread:726603
URL: http://www.dr-bob.org/babble/20080528/msgs/832635.html