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Re: Ritalin, NAC and Indium?

Posted by linkadge on June 5, 2008, at 8:26:08

In reply to Re: Ritalin, NAC and Indium?, posted by undopaminergic on June 5, 2008, at 4:59:27

There is no evidence I am aware of that suggests stimulants used at clincal doses for AD/HD are toxic to the brain.

Studies linking stimulants to neurotoxicity use doses that get people high. At these doses you are having major neurotransmitter release and are at risk of glutamatergic neurotoxicity and a correspoding increase in oxadative stress.

As mentioned DAT inhibitors can protect against the effecs of certain neurotoxins. This depends on deceased activity of the dopamine transporter. Chronic use can sometimes lead to compensatory dopamine transporter upregulation which may negate this effect.

Linkadge


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URL: http://www.dr-bob.org/babble/20080528/msgs/833055.html