Posted by SLS on June 10, 2008, at 14:55:22
In reply to Re: Mood Stablizer with ZERO serotonin effect? » linkadge, posted by SLS on June 10, 2008, at 11:10:29
Sorry about the inaccuracy. I confused the thalamus with the hippocampus.
Regarding the antidepressant properties of lamotrigine, my rationale is that:1. Lamotrigine reduces glutamate release in the hippocampus.
2. Hippocampal glutamatergic pathways leading to the nucleus accumbens are muted.
3. The function of these pathways is to inhibit dopamine release ("put the brakes on") in the nucleus accumbens.
4. Reduced firings of these glutamatergic pathways disinhibits dopamine release in the nucleus accumbens, thereby increasing dopaminergic activity there.
- Scott
poster:SLS
thread:833737
URL: http://www.dr-bob.org/babble/20080606/msgs/834010.html