Posted by bleauberry on July 10, 2008, at 16:35:18
In reply to Stablon (tianeptine) with SSRI?, posted by atmlady on July 9, 2008, at 12:31:27
I have often wondered if the serotonin effect of a drug really doesn't have much to do with the mood, but that it does other things such as set in motion other adaptive changes in receptors and hormones, turn certain gene-talk on or off, and create side effects of too much serotonin. I think people who truly are deficient in serotonin are the ones who respond almost immediately. Serotonin reuptake inhibitor/enhancer...way too generic and limited to explain what these drugs are really doing, I think.
Try visiting tianeptine.com. The drug does a lot of other stuff that sounds to me like much more meaningful and important than anything having to do with serotonin. Visit the manufacturer's site too. They hardly mention the serotonin effect at all. It's the other stuff, primarily neuronal plasticity, genetic communication, receptor communication, and dendrite growth, that gets the focus.
A while back I saw an abstract at pubmed where a patient was given a conventional antidepressant, it didn't work, then they were given tianeptine, it didn't work, and then they were given a conventional antidepressant plus tianeptine together and it did work. But, no mention of what the other antidepressant was.
I personally would have no hesitation in combining tianeptine with another antidepressant, admittedly in careful tip-toe dosing at first, and that may actually happen in the not-too-distant future.
poster:bleauberry
thread:839002
URL: http://www.dr-bob.org/babble/20080706/msgs/839154.html