diverse 5-ht receptor antagonists and depression

Posted by linkadge on July 20, 2008, at 21:34:55

I think it is interesting that certain 5-ht antagonists display antidepressant effects.
For instance, not only does 5-ht2a/c blockade appear to enhance AD effect and/or produce AD effect on its own, so does blockade of other 5-ht receptors such as 5-ht3, 5-ht6, 5-ht7 etc.
With blockade of so many different 5-ht receptors being able to produce AD effect, one wonders how much of the SSRI action is actually counteracting itself.
http://www.ncbi.nlm.nih.gov/pubmed/17314195?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_Discovery_RA&linkpos=5&log$=relatedarticles&logdbfrom=pubmed
http://www.ncbi.nlm.nih.gov/pubmed/18234190?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum
The 5-ht system is very complex.
Linkadge

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diverse 5-ht receptor antagonists and depression linkadge 7/20/08
Re: diverse 5-ht receptor antagonists and depression » linkadge Marty 7/21/08
Re: diverse 5-ht receptor antagonists and depressi Amigan 7/21/08
Re: diverse 5-ht receptor antagonists and depressi » Amigan Phillipa 7/21/08

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