Posted by Negcreep on July 25, 2008, at 6:33:10
In reply to Re: Agomelatine- Anyone tried it? Share your Info pls! » NegCreep, posted by Marty on July 24, 2008, at 13:59:34
Marty, Interesting about the Melatonin. I didnt realise it was being tested with depression. Still even if it does have some success with depression it probably wont to jack for anxiety (which is my main concern, ive got GAD). I also wasnt aware that SSRI targetted all 5HT receptors to some extent. That just makes me think that Agomelatine sounds even better because its not a 5HT like molecule it should only target the recptors it supposed to, limiting the side effects.
You asked if Agomelatines been pushed as a sedative. Well they claim that it will sort out your circadian rhythm whithout causing any increase in day time drowsniness....Bonus!
By "for the drugs" I did indeed mean agomelatine, currently not other drug out there targets this particular 5HT receptor combination, so its all new teritory. As for up regulation and poop out, this isnt something I know very much about....Ive not experienced it yet either (thankfully). I read somewhere once that SSRIs can fail on you after about a decade. Ive had to recently switch from citalopram to a TCA because it was giving me gastritis. So that sucks, TCA isnt as effective and i get drowsiness.
One of the reports I found was on here http://www.dr-bob.org/cgi-bin/pb/mget.pl?post=/babble/20080617/msgs/835310.html
I tried to get the guy to give more info but no reply as yet.
The other one I saw was a comment at the bottom of a article on agomelatine. I cant for the life of me find it again. But she was claiming to have been on it for a year in a clincal trial and said it was a completely "Blissful year", she was worried about haivng to change back to a SSRI when the trial finished.Now Im just hoping we get some more information on here about it. theres gotta be plenty of ppl out there , come on tell us what you think :)
poster:Negcreep
thread:841653
URL: http://www.dr-bob.org/babble/20080718/msgs/841941.html