Posted by Bob on July 26, 2008, at 22:05:56
In reply to Re: CAN SSRI's CAUSE BIPOLAR TO SHOW UP OR JUST SIDE A » Marty, posted by linkadge on July 25, 2008, at 16:15:01
> >It is likely that nobody will receive this Bp4 >diagnostic after only 1 or 2 med induced switch >into mania has it takes many years to confirm >the the sufferer doesn't switch into mania >without a change in meds.
>
> Thats true and unfortunately, many patients will still be given mood stabilizers to treat the AD induced mania. Sometimes these patients don't do well. They don't like mood stabilizers alone since they don't help the depression and the AD alone causes mania, so they end up on both classes of meds. Hopefully they will develop diverse targets for unipolar disorder to see if some of these patients might have fewer side effects on an AD with completely different mechanism. I think the AD's that mess the most with sleep seem to be the ones most capable of inducing mania.
>
> Some people think the AD induced mania is really just a form of disinhibition. The SSRI's can diminish executive function and can sometimes cause reckless or thoughtless behavior. Perhaps thats why wellbutrin has a lower switch rate to mania. It would likely enhance prefrontal cortex function that might leave the user in more control of their moods and behavior.
>> Linkadge
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>
This is somewhat like the predicament I have found myself in more than once, except instead of mania, it's usually irritated panic and akathisia. So, I've often been on combinations of depressing "mood stabilizers" in combination with initially activating anti-depressants. Eventually, the AD poops out and I'm severely fatigued, depressed, anhedonic, and drowsy.Meds I've taken that produced any kind of hypomania (I've never experienced full blown mania) would always fade out into depression.
- Bob
poster:Bob
thread:841813
URL: http://www.dr-bob.org/babble/20080718/msgs/842213.html