Posted by rotem on August 2, 2008, at 9:47:49
In reply to Re: Let's try that again... food for thought., posted by linkadge on August 1, 2008, at 18:38:33
I heard butyric acid (also called butyrate or sodium butyrate) is also a HDAC.
but from butter it doesn't cross the intestine.
the problem it is a two-edged sword : it can cause proliferaiotn, but also apoptosis- which is not good for neurons.
here is a citation from wikipedia
http://en.wikipedia.org/wiki/Butyric_acid
cellular proliferation, apoptosis and differentiation that may be either pro-neoplastic or anti-neoplastic, depending upon factors such as the level of exposure, availability of other metabolic substrate, and the intracellular milieu. Butanoate is thought by some to be protective against colon cancer. However, not all studies support a chemopreventive effect, and the lack of agreement (particularly between in vivo and in vitro studies) on butyrate and colon cancer has been termed the "butyrate paradox." There are many reasons for this discrepant effect, including differences between the in vitro and in vivo environments, the timing of butanoate administration, the amount administered, the source (usually dietary fiber) as a potential confounder, and an interaction with dietary fat. Together, the studies suggest that the chemopreventive benefits of butanoate depend in part on amount, time of exposure with respect to the tumorigenic process, and the type of fat in the diet.[3] Low carbohydrate diets like the Atkins diet are known to reduce the amount of butanoate produced in the colon.
[end of citation]Do you know of a way to consume butyric acid ?
Also, what about folic acid and B12 , that increase methylation. Maybe, therefore, there are shouldn't be consumed by depressed people?
poster:rotem
thread:843379
URL: http://www.dr-bob.org/babble/20080727/msgs/843653.html