Posted by bleauberry on August 7, 2008, at 19:08:08
In reply to Fluoxetine = 5-HT2c Potent antagonist ? ..confused, posted by Marty on August 5, 2008, at 19:39:36
>
> 5-HT2c is supposed to be the major culprit in the antidepressant sexual side effects. Fluoxetine is often reported has been one of the worst antidepressant when it comes to sexual side effects. Agreed ? .. now I stumble upon this:Actually no, not agreed. While all ssris had sexual side effects with me, prozac was by a long shot the friendliest.
>
> "Have you ever given a dose of fluoxetine (Prozac) to a patient and had them have an activation? Fluoxetine is the only other drug that has powerful 5HT2C antagonist properties; in fact, fluoxetine has more powerful antagonist properties than reuptake blocking properties."5ht2c antagonism blocks the effects of serotonin at that receptor, which is actually a good thing for sex, not a bad thing. Downstream effects as a result include release of more DA, NE, and 5ht. Levels of all 3 neuros increase in the brain from prozac but not from other ssris.
>
> Source: " Schizophrenia: From Circuits to Symptoms
> Stephen M. Stahl, MD, PhD. Improving Mood and Cognition: Serotonin 2C and 1A"
>
> URL:
> http://www.medscape.com/viewarticle/484929_5
>
> If Prozac is one of the most potent 5-HT2C and end up being one of the worst at the sexual level then ... there's way more to the story than just 5-HT2C .. Any thoughts ?
>
> /\/\artyThe potency as a 5ht2c antagonist is actually sex-friendly. Of course, the serotonin reuptake is powerful enough to over-ride much of it. Due to the 5ht2c antagonism, prozac has been called an atypical ssri.
And to say in a generalized manner that the 5ht2c receptor is responsible for sexual side effects is extremely oversimplified. It just aint that simple. Lots of stuff going on. And a great deal of interplay/interaction/shared duties between other receptors and other neuros.
poster:bleauberry
thread:844424
URL: http://www.dr-bob.org/babble/20080805/msgs/844847.html