Posted by linkadge on August 12, 2008, at 15:56:22
In reply to Re: Amphetamine neurotoxicity in therapeutic doses, posted by desolationrower on August 10, 2008, at 16:50:58
I don't think this study should be shrugged off. I think this study is applicable to human usage, and I would personally be very concerned about the potential for theraputic use of amphetamines and other related compounds to cause neurotoxicity.
You can bet though that its not Shire that is going to be rushing out any time soon to fund follow up studies.
Also, DAT transporters are *not* upregulated in ADHD. This is a stupid hypothesis (which is not supported by the majority of studies) based on the mechanism of action of the stimulants. Its just about as believable as the notion that serotonin transporters are elevated in depression.
Linkadge
poster:linkadge
thread:845093
URL: http://www.dr-bob.org/babble/20080805/msgs/845722.html