Posted by SLS on August 16, 2008, at 12:09:24
In reply to Nortriptyline vs. Desipramine, posted by Bob on August 16, 2008, at 11:53:45
> Why does Nortriptyline seem to be a more popular choice of AD than Desipramine, considering that the latter might be considered a slightly cleaner or more pure norephinephrine enhancer than Nortriptyline? There are recommendations for combining Nortriptyline with SSRI's, but I haven't really seen the same for Desipramine.
>Sometimes "dirty" is better. Unlike desipramine, nortriptyline blocks 5-HT2a/c receptors in addition to being a modest 5-HT reuptake inhibitor. I find nortriptyline to be a more pleasant drug than desipramine. Desipramine is certainly a good drug, and many people will respond to it and not respond to nortriptyline.
- Scott
poster:SLS
thread:846648
URL: http://www.dr-bob.org/babble/20080814/msgs/846653.html