Posted by Quintal on October 1, 2008, at 17:30:19
In reply to Why is Zyprexa so good for anxiety...??, posted by jms600 on September 29, 2008, at 17:57:54
I think a lot of the benefits are to do with its action at serotonin receptors - Zyprexa binds more strongly to the serotonin receptors (5-HT2A/C and 5-HT3) than it does to the dopamine receptors, and other drugs that block these receptors (e.g. Remeron, Serzone, agomelatine, Periactin, ondansetron etc) tend to be anxiolytic and have some antidepressant properties. Like you I've found there's something about Zyprexa that hits a spot other drugs don't reach. Again, I think it has something to do with the serotonin antagonism and the effect this has on mood, panic and anxiety that is different to benzos and other anti-anxiety drugs. Zyprexa is I think the only AP that is a 5-HT3 antagonist bar Clozaril. Years ago I wanted to try ondansetron (5-HT3 blocker) because there had been some evidence it and other 5-HT3 antagonists were useful in anxiety disorders. I think Remeron did give me a similar feeling (another strong 5-HT3 blocker), but like Zyprexa it came with such strong sedation that it was impossible to say what was doing what. I would like to try a pure 5-HT3 blocker though just out of curiosity.
Q
poster:Quintal
thread:854809
URL: http://www.dr-bob.org/babble/20080926/msgs/855133.html