Posted by bleauberry on October 19, 2008, at 19:21:04
In reply to Mirapex plus abilify plus Parnate, posted by uncouth on October 19, 2008, at 9:33:04
Topics like this are way too complicated to armchair quarterback. Even to say one drug does something to a D2 receptor and another does something else to it is extremely oversimplified. There is just so much we don't know. Even the above types of ways of thinking about things is probably only a fraction of what is actually going on. What we know is mostly theory, not fact, and much of it is based on mice or rats, not the same as humans, and the particular ways of measuring things in humans is riddled with flaws and assumptions that pile up on top of one another.
I don't recall where it is, but surfing at pubmed a couple months ago I saw a study where a dopamine agonist was added to an antipsychotic. I forget what the symptoms were or why the agonist was needed. In any case, the symptoms were fixed and there was no loss of efficacy of the antipsychotic. So, in this case, the two went together well, did their respective jobs without interfering with each other. In our simplified way of thinking that doesn't make sense. But again, it is my opinion there is so much more going on than a simple D2/D3 picture.
It is the best we have and it is our nature to try to make sense of things. But in the end, the actual realworld result of consuming something is all that matters.
Personal trial is the only way to find out.
poster:bleauberry
thread:858222
URL: http://www.dr-bob.org/babble/20081016/msgs/858315.html