Posted by bleauberry on November 8, 2008, at 21:13:08
In reply to amisulpride/ solian, posted by sigolene on November 8, 2008, at 5:33:51
Sulpride is very similar, but is also just different enough that it may not have the same bad effects.
While others have mentioned Abilify, I kind of disagree with that. I think the closest thing among the atypicals would be low dose risperdal. I believe it has pretty strong presysnaptic blockade at low doses similar to risperdal, though it also has some serotonin stuff that amisulpride doesn't. Amisulpride is unique in its selectivity for dopamine and nothing else. Zyprexa might also provide some benefit, though not as directly as amisulpride, since zyprexa does a bunch of other stuff too that would cloud the picture. Abilify, I dunno. It is not only a dopamine blocker, but also a dopamine agonist, and a serotonin agonist/antagonist, and well, it is a complicated one. I don't see that as being very similar to amisulpride.
I wish your doctor could get a better handle on exactly what the gut problems are so you could address those directly without interrupting a treatment that is working for you. The gut is a lot easier to treat than the mind.
I mean, basics. Do you take a daily high dose of 35billion to 50billion units of a probiotic with 7 or more strains in it? That alone can do wonders. How about digestive enzymes to help your gut work better? How about a gluten sensitivity test to see if maybe you just need to avoid gluten products? (wheat, barley) Excellent substitutes made from rice, corn, and other flours. Another very common gut allergen is cow dairy products.
It sounds to me like amisulpride is not the cause of any problems, but rather the trigger that is highlighting some problems that were already there but not yet noticed. It just exaggerated them to a point of noticing. Maybe?
Anyway, try treating the gut first. Only after a month of doing that aggressively with no progress would I consider switching meds.
I can't remember the name. Triflurophenazine? Something like that. I would have to try to look it up. It is an older antipsychotic. I read in a Dr Stahl pharmacology book years ago that drug is the closest thing to amisulpride. Other than that, in order, I would go for sulpride, risperdal, zyprexa, all in very low doses as you would do with amisulpride.
poster:bleauberry
thread:861423
URL: http://www.dr-bob.org/babble/20081106/msgs/861642.html