Posted by bleauberry on November 11, 2008, at 20:52:39
In reply to Lexapro to Cymbalta -ADVICE PLEASE, posted by Justherself54 on November 11, 2008, at 2:18:03
I remember communicating with one guy who failed maois but then went into remission on a combination of cymbalta+milnacipran+wellbutrin. He had previously gotten worse or no better on just about every other med you can think of.
Another person it was adderall+milnacipran. In clinical studies, milnacipran by itself has worked on treatment resistant depression. In a small study, 3 out of 5 treatment resistant patients went into remission on 100mg milnacipran+.05mg risperdal. Something nice about that combo. Another lady same thing, it was milnacipran+zyprexa.Some points I wanted to make:
Look to meds you haven't tried. Don't go backwards where you've already been.
If you do go to old meds, combine them with things of different mechanisms. For example, stimulants or antipsychotics. Prozac+zyprexa is a pretty powerful combo and I don't know why it is used more often. It worked for me for many years, especially when I added adrafinil (similar to provigil) to it.
Look to meds around the world, not just the ones the FDA is in bed with. Japan's number one med is milnacipran. You've also got stablon and amisulpride to look at.
Lexapro to cymbalta. Sure, that switch has even been done in a study. Those who did a straight across switch had a much easier time than those who started from scratch on cymbalta. I personally wouldn't expect any great things to happen with cymbalta though. You're going to have to add a zyprexa or risperdal or milnacipran or ritalin or adderall or dexedrine or wellbutrin to it, at least 2 meds and maybe 3. I don't think any single med is going to do it, and I don't think just looking to increase neurotransmitter levels is going to do it either. Different mechanisms needed. All this is just my opinion, no right or wrong.
poster:bleauberry
thread:862231
URL: http://www.dr-bob.org/babble/20081106/msgs/862411.html