Posted by desolationrower on November 12, 2008, at 12:22:17
In reply to Re: Replicating agomelatine?, posted by West on November 12, 2008, at 7:24:57
> > This is a question to those who are fairly familiar with receptor action and drugs modes of action. If there was a dietary supplement that worked on seratonin and melatonin, would it even come close to working like agomelatine? Such as something with St. John wort or Sam-E mixed with melatonin? Or is that just a ridiculous concept?
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> Agomelatine must exert its antidepressant effect through 5HT-2c antagonism since its other major action, melatonin agonism, is famously depressogenic.
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> In one trial it was superior to sertraline although in 2006 the EMEA refused to grant license for its use on grounds of efficacy.
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> SJW is an SNDRI, SamE raises DA, NE and re-releaser of 5-HT. Melatonin is often bad for depressed people.Melatonin is not 'famously depressogenic.' There is some evidence suggesting it worsens depression, and some evidence indicating it helps. It depends on the person, and taking it properly.
As far as replicating, i can't think of any 5ht2c antagonists that are nonpharmaceuticals, but ther are a few drugs, like low doses of ziprasidone or fluoxetine that you could try.
-d/r
poster:desolationrower
thread:862472
URL: http://www.dr-bob.org/babble/20081106/msgs/862534.html