Posted by Quintal on November 13, 2008, at 11:44:49
In reply to Stablon (Tianeptine) vs. SSRIs, posted by bearfan on November 13, 2008, at 3:50:40
Most studies have found tianeptine is as effective as SSRIs and generally better tolerated. A lot of people seem dissapointed that tianeptine doesn't feel very strong. I tended to feel pretty drugged on SSRIs, but not on tianeptine. There isn't much of a feeling of it doing anything, so I was surprised at how quickly my depression lifted. It took me back to baseline in a few days, but didn't take me beyond it - I don't feel inappropriately happy or calm. As far as sex goes, tianeptine heightens tactile sensation (my skin was completely numb on Paxil) and sometimes libido. There is a report of nymphomania in the literature. As far as I'm concerned tianeptine is the model of an ideal antidepressant and we need more drugs like it.
Here is a review of five studies comparing tianeptine to SSRIs - two on Prozac and Paxil, and one on Zoloft:
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1: Encephale. 2003 Jul-Aug;29(4 Pt 1):322-8.Click here to read Links
[A meta-analysis of randomized controlled trials of tianeptine versus SSRI in the short-term treatment of depression]
[Article in French]Olié JP, Baylé F, Kasper S.
Département Universitaire de Psychiatrie, Hôpital Sainte-Anne, 7, rue Cabanis, 75014 Paris.
A meta-analysis was performed to compare the efficacy of tianeptine and selective serotonin reuptake inhi-bitors (SSRI) in the short-term treatment of depression. Consecutive selection and inclusion processes allowed five stu-dies to be selected: two studies on tianeptine versus fluoxetine, two studies on tianeptine versus paroxetine, and one study on tianeptine versus sertraline. A total of 1 348 patients were included in the five studies; 681 subjects received an SSRI and 667 tianeptine. A strict step-by-step methodology was applied in order to legitimize this meta-analysis and to interpret the results. Considering all the patients or those with a Montgomery-Asberg Depression Rating Scale (MADRS) inclusion score greater or equal than 28, none of the assessed parameters (MADRS total score and responder rate) revealed any significant difference between the two treatment groups. Further analysis based on clinical global impression (CGI) items found no significant difference, except for CGI item 3 (therapeutic index), where a tendency (p=0.06 or 0.07 depending on the methodology) was found in favor of tianeptine. All in all, this study confirmed that tianeptine is at least as effective as SSRI, with a trend for a better acceptability profile in the treatment of depressed patients.
PMID: 14615702 [PubMed - indexed for MEDLINE]
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Q
poster:Quintal
thread:862751
URL: http://www.dr-bob.org/babble/20081106/msgs/862819.html