Posted by jedi on November 22, 2008, at 3:28:27
In reply to tranylcypromine + mirtazapine?, posted by CaptainAmerica1967 on November 21, 2008, at 21:02:44
> Has anyone used mirtazapine with tranylcypromine? I had used phenelzine for refractory depression for about fifteen years and it stopped working in 2003 and have been on Cymbalta since, but I haven't been the same and am going to go on tranylcypromine and maybe a tricylic like amitriptyline with it, but don't want the TCA side effects so I thought about mirtzapine (tetracylic)?
Hi,
I would think that the combination of mirtazapine with a MAOI would have a high risk of serotonin syndrome. Each medication increase serotonin by different mechanisms, thus potentially raising the serotonin to too high a level.I have used nortriptyline with phenelzine in the past. The side effects of nortriptyline seem to be less than amitriptyline, and nortriptyline is the major active metabolite of amitriptyline. The TCAs that have a very small affect on serotonin are relatively safe with the MAOIs.
Be Well,
Jedi
poster:jedi
thread:864556
URL: http://www.dr-bob.org/babble/20081114/msgs/864593.html