Posted by KarenRB53 on November 24, 2008, at 21:25:05
In reply to Trileptal-Prozac Interaction? Cam--any insight?, posted by lizbeth on April 30, 2002, at 14:29:24
> Hello,
>
> I've been diagnosed BPII since March 2001. Was maintained on 625 of Depakote Sprinkle (regular Depakote had too many GI side effects). with 20-30 mg. of Prozac since then (concomitant depression). Am seeing a psychopharmacologist who I trust and who's been a good partner in making adjustments.
>
> I decided to explore other anticonvulsants as I believe the Depakote was blunting me too much cognitively at work. I started Trileptal, the newer version of Tegretol, 7 days ago (no washout on Depakote). My prescription is 450, 300 at night, 150 in morning.
>
> I had fairly significant side effects at the 450 mg. dose. I've done some research and it seems that Prozac raises the blood level of carbemapezine (tegretol) and I would intuit, Trileptal. I've been best when I skipped a day on the Prozac. I've gone down as low as 150 on the Trileptal last night but as soon as I took 30 mg. of Prozac this morning, the dizziness and yuckiness took over.
>
> I want to give the Trileptal a chance, already feeling clearer cognitively, even with all the side effects. My fiance thinks I should try taking the Prozac at night. I'm going to try stopping the Prozac for a few days and see if I'm better. I'm open to staying with Trileptal and looking for a new AD if necessary (or maybe just Trileptal at 450 will be enough?). Effexor XR has worked o.k. for me in the past.
>
> Compounding things, I think I may be one of those "poor metabolizers" with a funky P450 system because it always seems like need lower doses with meds that hit that site. Also on Claritin, Protonix (for heartburn), Singulair and Advair 250/50 (Asthma).
>
> Thanks in advance for any insight.
> Lizbeth
>
>
Hi: Just found this posting and hope you read this. I'm thinking of using the Trileptal with Prozac and wondering if you were able to stay on the combination or did you have to switch to another antidepressant?Thanks, Karen
poster:KarenRB53
thread:104533
URL: http://www.dr-bob.org/babble/20081123/msgs/865106.html